IMMUNOLOGIC AND BIOLOGIC CHARACTERIZATION OF ANTISERA TO BEEF THYROTROPIN PREPARATIONS*

Immunologic and Biologic Characterization of Antisera

Sensitive immunologic techniques and more purified preparations of bovine pituitary thyrotropin have made it possible to re-examine the question of whether thyrotropin acts as an antigen upon injection into heterologous species. This possibility was first indicated by Werner (1, 2) in 1936, to explain the loss of responsiveness to thyrotropin which Collip and Anderson (3) previously had observe...

Immunologic responses to therapeutic biologic agents.

Recombinant protein technology and the subsequent development of biologic agents for pharmacotherapy have greatly improved the treatment of a wide variety of diseases in humans. These products are subject to reactions not previously seen in other drug classes. Additionally, subtle alteration in the manufacture or administration of a biologic agent may cause reactions in subjects who previously ...

Biologic activity of digoxin-specific antisera.

Digoxin-specific antibodies are capable of removing essentially all intracellular digoxin from rat renal cortical slices or from human erythrocytes. In removing digoxin from erythrocytes, these antibodies are capable of reversing an effect of the drug on cellular potassium transport. This study provides direct evidence that antibodies are capable of removing, and thereby reversing the biologica...

synthesis and characterization of some macrocyclic schiff bases

ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...

Immunologic and Biologic Study of Human Chorionic Gonadotropin.